Info
Associate Professor of Genetics and Bioengineering at Stanford University, and ChEM-H Institute fellow. Her laboratory develops and applies new microfluidic platforms for quantitative, high-throughput biophysics, biochemistry, and single-cell genomics. Key technologies include HT-MEK (high-throughput microfluidic enzyme kinetics, characterizing >1,100 enzyme mutants) and MITOMI 2.0 (measuring binding affinities for up to 4,000 transcription factor-DNA interactions in parallel). PhD in physics at Stanford (Steve Block lab, single-molecule kinesin studies); postdoc with Joe DeRisi at UCSF.
DiffUSE relevance
Fordyce’s high-throughput biophysics platforms could provide functional validation data at a scale that matches the throughput of diffuse scattering data collection. If DiffUSE can measure conformational dynamics for many protein variants, Fordyce’s microfluidic enzyme kinetics could provide the complementary functional readout (does dynamics change predict activity change?).
Key Relationships
- Stanford University — Genetics + Bioengineering
- HT-MEK / MITOMI — high-throughput microfluidic platforms
- UCSF — postdoc with Joe DeRisi (Bay Area connection)
- NIH New Innovator and Pioneer Awards, NSF CAREER, 2023 Eli Lilly Award in Biological Chemistry
Sources
- Fordyce Lab: http://www.fordycelab.com/
- Stanford Bioengineering: https://bioengineering.stanford.edu/people/polly-fordyce
- Wikipedia: https://en.wikipedia.org/wiki/Polly_Fordyce