wwPDB Integrative and Hybrid Methods Task Force
Managed by the wwPDB and funded by the NSF, DOE, and NIH.
In 2014, the wwPDB convened an Integrative/Hybrid Methods (IHM) Task Force and sponsored a Workshop held at the European Bioinformatics Institute (EBI). The purpose of the Workshop was to engage a community of experts to make recommendations for how to responsibly archive integrative structures.
A white paper was published (Sali et al., 2015) and two working groups were established: the Federation Working Group was to address the issues of data federation and the Model Working Group was tasked with helping set up the framework for model representation, validation, and visualization.
A white paper was published (Sali et al., 2015) and two working groups were established: the Federation Working Group was to address the issues of data federation and the Model Working Group was tasked with helping set up the framework for model representation, validation, and visualization.
The PDB-IHM is a wwPDB project developed by a multi-disciplinary team of researchers and developers from RCSB PDB at Rutgers, the State University of New Jersey, University of California San Francisco, and University of Southern California.
Team leaders
Dr. Andrej Sali Helen M. Berman Stephen K. Burley Dr. Brinda Vallat Dr. Carl Kesselman Dr. Benjamin Webb Dr. Monica Sekharan Dr. Arthur Zalevsky
Funding
PDB-IHM is partly funded by NSF awards DBI-2112966, DBI-2112967, and DBI-2112968 and also as part of RCSB PDB core operations through the NSF (DBI-2321666), the DOE (DE-SC0019749), and the NIH (R01GM157729).
DBI-2112966 to Rutgers Performance start: 2021-09-01 Performance end: 2024-08-31 Obligation: 720,000.00
DBI-2112967 to UCSF Performance start: 2021-09-01 Performance end: 2024-08-31 Obligation: 690,000.00
DBI-2112968 to USC Performance start: 2021-09-01 Performance end: 2024-08-31 Obligation: 386,092.71
Previously, development of the IHMCIF dictionary and the PDB-IHM system were funded by NSF awards DBI-1519158, DBI-1756248, and DBI-1756250. Vallat B et al., J Mol Biol. 2025; 168963. doi: 10.1016/j.jmb.2025.168963 Vallat B et al., J Mol Biol. 2024; 436(17): 168546. doi: 10.1016/j.jmb.2024.168546 Vallat B et al., Acta Cryst. 2021; D77: 1486-1496. doi: 10.1107/S2059798321010871 Berman HM et al., Structure. 2019 Dec 3; 27(12): 1745-1759. doi: 10.1016/j.str.2019.11.002 Vallat B et al., J Biomol NMR. 2019 Jul; 73(6-7): 385-398. doi: 10.1007/s10858-019-00264-2 Vallat B et al., Structure. 2018 Jun; 26(6):894-904. doi: 10.1016/j.str.2018.03.011 Burley SK et al., Structure. 2017 Sep; 25(9):1317-1318. doi: 10.1016/j.str.2017.08.001 Sali A et al., Structure. 2015 Jul; 23(7):1156-1167. doi: 10.1016/j.str.2015.05.013 For information on how to cite PDB-IHM, refer to the FAQ page.
2019 PDB IHM Task Force Participants Initial PDB IHM Task Force Participants PDB IHM Federation Working Group Members PDB IHM Model Working Group Members PDB IHM Ex-officio members from the wwPDB PDB IHM Model Developer Group Members