Info
Professor in the Departments of Bioengineering and Therapeutic Sciences and Pharmaceutical Chemistry at the School of Pharmacy, UCSF. Leads the Sali Lab, which develops and applies computational methods for integrative determination of the structures and dynamics of macromolecular assemblies. Principal developer of the Integrative Modeling Platform (IMP), the open-source software suite for combining data from X-ray crystallography, cryo-EM, cross-linking mass spectrometry, SAXS, and other experiments into unified structural models. Co-architect of the PDB-IHM archive (the wwPDB repository for integrative/hybrid methods structures) alongside Helen M. Berman.
DiffUSE relevance
Sali’s integrative modeling framework is one potential route for incorporating diffuse scattering data into multi-source structural models. If DiffUSE produces diffuse scattering-derived constraints on protein dynamics, IMP could be the platform that integrates those with crystallographic, cryo-EM, and cross-linking data. Sali is at UCSF, same institution as Jaime Fraser (DiffUSE PI), Yifan Cheng, and Willow Coyote-Maestas.
Key Relationships
- UCSF — same institution as Jaime Fraser, Yifan Cheng, Willow Coyote-Maestas
- IMP (Integrative Modeling Platform) — principal developer
- PDB-IHM — co-architect of the integrative/hybrid methods archive
- Helen M. Berman — PDB-IHM co-founder
- Torsten Schwede — wwPDB task force-ModelCIF Working Group co-chair
- PDB IHM Model Working Group Members — co-chair (listed in existing wiki page)
- MODELLER — earlier widely-used homology modeling software
Sources
- Sali Lab: https://salilab.org/
- UCSF profile: https://profiles.ucsf.edu/andrej.sali