University of Washington / Institute for Protein Design
Info
Computational structural biologist in the David Baker group at the University of Washington Institute for Protein Design. Developer of RosettaHoles and RosettaHoles2, packing-based structure validation tools built on Rosetta. RosettaHoles discriminates real from computationally-generated structures and flags problematic regions in PDB models - an approach complementary to MolProbity’s all-atom contacts.
Key Relationships
- David Baker — group leader at UW Institute for Protein Design
- RosettaHoles / RosettaHoles2 — packing-based validation tools
- More recently contributed to Baker Lab de novo design work (RFdiffusion and follow-ons)
- X-Ray Validation Task Force member (Read et al., Structure 2011)
Sources
- RosettaHoles2 (Sheffler & Baker, Protein Science 2010): https://onlinelibrary.wiley.com/doi/full/10.1002/pro.458