computational modeling software-dev
Info
Comprehensive protein structure prediction, design, and modeling suite developed primarily in the David Baker group at the University of Washington Institute for Protein Design, with contributions from the global RosettaCommons consortium. Underpins much of de novo protein design and structural modeling; RosettaHoles (Sheffler & Baker) applies Rosetta energy functions to packing-based structure validation.
Key Relationships
- David Baker — principal investigator
- William H. Sheffler — RosettaHoles / RosettaHoles2 for validation
- University of Washington Institute for Protein Design — host
- Evolved into RoseTTAFold, RFdiffusion, and other ML-era tools