Info

EPU is Thermo Fisher Scientific’s proprietary automated data acquisition software for their Krios, Glacios, and Tundra cryo-TEM platforms. Commercial, closed-source. Integrates with Embedded cryoSPARC Live for real-time processing.

Commercial lock-in

EPU is bundled with Thermo Fisher microscopes, creating a vertically integrated workflow: EPU (acquisition) + Embedded CryoSPARC Live (processing). This is a significant commercial dynamics point. SerialEM is the open-source alternative.

Key Relationships