Lawrence Berkeley National Lab (LBNL)
Beamline Modeling #ucsf #lbnl #modeling beamline
Lawrence Berkeley National Laboratory / UCSF / ALS
Info
Full Adjunct Professor, Department of Biochemistry and Biophysics, UCSF. Director of Macromolecular Crystallography Beamline 8.3.1 (the “TomAlberTron”) at the Advanced Light Source, Lawrence Berkeley National Laboratory. Faculty Scientist in the Molecular Biophysics and Integrated Bioimaging (MBIB) Division at LBNL. Expert in radiation damage, detector performance, and X-ray scattering physics. Has written absolute-scale simulators for both conventional MX and femtosecond nanocrystallography.
DiffUSE role
James Holton is a DiffUSE team member (listed on diffuse.science/members). He directs the exact beamline (ALS 8.3.1) where the Fraser Lab collects DiffUSE data. His expertise in X-ray scattering physics is directly relevant to diffuse scattering data quality and background modeling. Co-author with Jaime Fraser on Mac1 and other DiffUSE-relevant publications.
Affiliations
- UCSF — Department of Biochemistry and Biophysics
- Lawrence Berkeley National Laboratory — MBIB Division
- ALS — Beamline 8.3.1 Director
- DiffUSE team member
Key Relationships
- Beamline 8.3.1 Participating Research Team headed by Jaime Fraser and Robert Stroud
- PRT includes UCSF, UC Berkeley, and Relay Therapeutics
- Co-located at LBNL with Paul Adams (PHENIX) and Aaron Brewster (DIALS, NIAC Chair)
- Co-author with Fraser on Bayesian multi-state modeling paper (2025)
- PhD with Tom Alber at UC Berkeley (Alber spearheaded construction of Beamline 8.3.1)
Key Publications
- Bayesian multi-state multi-condition modeling (with Hancock, Fraser, Adams, Sali) — bioRxiv 2025
- Crea