Fieldnotes

Nozomi Ando

leader mx sas computational beamline

Cornell University / CHESS

Info

Associate Professor of Chemistry and Chemical Biology at Cornell University. Her lab harnesses information on correlated displacements contained in the diffuse scattering from protein crystals to understand protein allostery. One of a small number of groups worldwide establishing diffuse X-ray scattering as a quantitative window into protein motions. Editor of Crystallography of Protein Dynamics (Methods in Enzymology, Volume 688). Uses CHESS beamlines for experimental data collection.

DiffUSE role

Nozomi Ando is a DiffUSE team member (listed on diffuse.science/members). Her experimental work on the project is conducted at CHESS. She is the DiffUSE PI for data collection alongside James Holton (beamline scientist at ALS) and Steve Meisburger (CHESS staff scientist). Her lab developed the “robust total X-ray scattering workflow” (Meisburger, Case & Ando, Nature Communications 2023) that is foundational to DiffUSE data processing.

Affiliations

  • Cornell University, Department of Chemistry and Chemical Biology — Associate Professor
  • CHESS (Cornell High Energy Synchrotron Source) — active user and collaborator

Awards and honors

  • 2024 ASBMB Mildred Cohn Young Investigator Award — “for outstanding and field-defining contributions to protein dynamics” and dedication to diversity, equity, and inclusion in STEM
  • Schmidt Polymaths cohort (2025) — selected for breakthroughs in diffuse X-ray scattering and structural enzymology

Conference and workshop leadership

  • Co-Director, 2022 Erice International School of Crystallography — 57th Course: “Diffuse Scattering: The Crystallography of Dynamics, Defects, and Disorder” (with Andrew Goodwin, Oxford). This was the first Erice school on diffuse scattering. Ando also taught “Protein correlated motions” and ran a data reduction workshop (ando-lab/erice-2022-data-reduction on GitHub).

Key Relationships

  • DiffUSE team (diffuse.science/members): alongside Jaime Fraser (PI, UCSF), James Holton (ALS), Steve Meisburger (CHESS), Michael Wall (LANL), Stephanie Wankowicz (Vanderbilt), and Andy Burnim (PM)
  • Steve Meisburger — CHESS staff scientist; close collaborator on total X-ray scattering workflow (co-author, Nature Communications 2023)
  • Michael Wall — LANL; MD simulations of biological diffuse scattering; co-lecturer at 2022 Erice
  • Jaime Fraser — DiffUSE PI; multi-conformer modeling / qFit connection
  • David Case — Rutgers; AMBER force fields used in diffuse scattering MD simulations (co-author on Nature Communications 2023)
  • Daniel Keedy — multi-conformer modeling community overlap
  • Marcus Fischer — multi-conformer crystallography community overlap
  • Andrew Goodwin (Oxford) — 2022 Erice co-director (materials science side of diffuse scattering)
  • Ariana Peck (SLAC) — former Stanford; models of protein diffuse scattering; 2022 Erice lecturer
  • Doeke Hekstra (Harvard) — time-resolved macromolecular crystallography; 2022 Erice lecturer
  • Kartik Ayyer (MPSD Hamburg) — XFEL protein diffuse scattering; 2022 Erice lecturer

Key Publications

  • Meisburger, Case & Ando, “Robust total X-ray scattering workflow to study correlated motion of proteins in crystals,” Nature Communications (2023)
  • Ando (ed.), Crystallography of Protein Dynamics, Methods in Enzymology Vol. 688 (Elsevier)
  • Wall, Ando, et al., “Diffuse X-ray scattering from correlated motions in a protein crystal,” Nature Communications (2020)

Sources

Graph View

Backlinks