Hospital for Sick Children / University of Toronto
Info
Senior Scientist in the Molecular Medicine program at Hospital for Sick Children (joined 2006), jointly appointed Professor in the Departments of Biochemistry and Medical Biophysics at the University of Toronto. His laboratory uses electron cryomicroscopy (cryo-EM) to study biomolecular machines, including mitochondrial ATP synthase, mycobacterial energy metabolism (with relevance to tuberculosis), and neuronal ATP biology relevant to epilepsy. Elected Fellow of the Royal Society of Canada (FRSC) in 2024.
wwPDB role
Chair of the wwPDB Scientific Advisory Committee; also serves as the 3DEM community representative on the AC. Hosted the 17 October 2025 virtual AC meeting.
Affiliations
- Hospital for Sick Children — Senior Scientist, Molecular Medicine (2006-)
- University of Toronto — Professor, Departments of Biochemistry and Medical Biophysics
Training
- PhD (1998-2001): University of Cambridge, MRC-LMB, supervised by Sir John E. Walker (Nobel 1997, ATP synthase) and Richard Henderson (Nobel 2017, cryo-EM)
- Postdoctoral fellow (2002-2003): MRC Laboratory of Molecular Biology
- Postdoctoral fellow (2003-2005): Banting and Best Department of Medical Research, University of Toronto
Committees & service
- wwPDB Scientific Advisory Committee — Chair, 3DEM Representative
- Member of the 3DEM community (as representative on the wwPDB AC)
Key Relationships
- Training lineage runs through two Nobel Laureates at MRC Laboratory of Molecular Biology: Sir John E. Walker (ATP synthase, Nobel 1997) and Richard Henderson (cryo-EM, Nobel 2017)
- Active in the wwPDB validation and EMDB community alongside Sjors Scheres, Giulia Zanetti, and Kyle Morris on the current Advisory Committee
Honors
- Fellow, Royal Society of Canada (2024)
Sources
- SickKids profile: https://sickkids.ca/en/staff/r/john-rubinstein/
- wwPDB 2025 Advisory Committee report: https://cdn.rcsb.org/wwpdb/docs/about/advisory/wwpdbac2025-report.pdf